'Anguish' in the Bible

After screaming out and throwing him into a terrible convulsion, it came out. The boy looked so much like a corpse [so still and pale] that many [of the spectators] said, “He is dead!”

For nation will rise up against nation, and kingdom against kingdom; there will be earthquakes in various places; there will be famines. These things are the beginning of the birth pangs [the intolerable anguish and suffering].

and He said to them, "My heart is oppressed with anguish to the very point of death: wait here and keep awake."