'Hopeless' in the Bible

Hoping in spite of hopeless circumstances, he believed that he would become "the father of many nations," just as he had been told: "This is how many descendants you will have."

For [godly] sorrow that is in accord with the will of God produces a repentance without regret, leading to salvation; but worldly sorrow [the hopeless sorrow of those who do not believe] produces death.